ActX makes genetics part of practical medical practice by building personalized medicine support into the physicians’ current workflow. Every prescription written is automatically checked against the patient’s genetics for side effects and efficacy. ActX covers almost all U.S. prescription drugs for which there is evidence of a genomic effect. For example, a significant percentage of the U.S. population likely gets no pain relief from codeine, based on their genetics. ActX can automatically alert clinicians to these patients right at the point of care, when physicians are writing a prescription.
Inside NewCrop, the ActX Patient Genomic Profile shows actionable, serious genetic medical risks such as actionable disease risks as well as carrier status. For example, patients with Lynch syndrome, a genetic condition, can have up to a 70% lifetime risk of colorectal cancer, which can be detected at an early stage through colonoscopy starting at a young age.
Using a single saliva-based test rather than multiple small panels, ActX is a full, turn-key solution for integrating Actionable Genomics℠ into the everyday medical practice. The ActX Service is evidence based, is continuously updated, includes references, and evaluates the strength of the evidence and the quality of the patient data.
In addition to providing real time Genomic Decision Support℠, ActX makes it easy to obtain patients’ genetics using a small amount of saliva. After a physician authorizes a patient through NewCrop, the patient will receive an email allowing them to sign up for the ActX Service. The patient will then sign up on the ActX website, pay for the service (the service is currently paid for by patients and not covered by insurance), and receive a saliva collection kit at their home. The patient provides one cc of saliva and then mails it directly to our CLIA-certified laboratory, where it will be genotyped or sequenced.
After quality assurance, the ActX Genomic Decision Support service will be activated. The authorizing physician will be alerted by a notice in their EHR inbox when the patient's data is available, and when any immediate or subsequent serious medical risks are found. Every time a prescription is written, it will be checked for drug-genome interactions, and an up-to-date patient Genomic Profile can be checked in Allscripts at any time.